Dissecting Requirements for Auto-inhibition of Actin Nucleation by the Formin, mDia1
نویسندگان
چکیده
منابع مشابه
The Mouse Formin mDia1 Is a Potent Actin Nucleation Factor Regulated by Autoinhibition
Formin proteins are widely expressed in eukaryotes and play essential roles in assembling specific cellular actin-based structures. Formins are defined by a Formin Homology 2 (FH2) domain, as well as a proline-rich FH1 domain that binds the actin monomer binding protein, profilin, and other ligands. Constructs including FH2 of budding yeast Bni1 or fission yeast Cdc12 formins nucleate actin fil...
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Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1
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متن کاملCrystal Structure of the Formin mDia1 in Autoinhibited Conformation
BACKGROUND Formin proteins utilize a conserved formin homology 2 (FH2) domain to nucleate new actin filaments. In mammalian diaphanous-related formins (DRFs) the FH2 domain is inhibited through an unknown mechanism by intramolecular binding of the diaphanous autoinhibitory domain (DAD) and the diaphanous inhibitory domain (DID). METHODOLOGY/PRINCIPAL FINDINGS Here we report the crystal struct...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2005
ISSN: 0021-9258
DOI: 10.1074/jbc.m411605200